Author

E. V. Minikel

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Research Focus:cell type annotation· 1 Research Focus:drug response / drug discovery· 1 Assay:proteomics· 1

Frequent Co-Authors

A. G. Reidenbach· 2 shared A. J. Leed· 2 shared M. F. Mesleh· 2 shared S. L. Schreiber· 2 shared S. M. Vallabh· 2 shared A. I. Chan· 1 shared A. J. Campbell· 1 shared C. T. Lemke· 1 shared

Activity by Year

2019-2020 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersBiochemistry

A. G. Reidenbach

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2 papers

Recent·Most cited

Multimodal small-molecule screening for human prion protein binders

A. G. Reidenbach, M. F. Mesleh, D. Casalena, S. M. Vallabh, J. L. Dahlin, A. J. Leed, A. I. Chan, D. L. Usanov, J. B. Yehl, C. T. Lemke, A. J. Campbell, R. N. Shah, O. K. Shrestha, J. R. Sacher, V. L. Rangel, , E. V. Minikel

This study screens for small-molecule binders of the human prion protein using multiple methods but finds only a weak binder with no therapeutic potential.

bioRxiv · Jun 18, 2020Biochemistry

Characterization of the prion protein binding properties of antisense oligonucleotides

A. G. Reidenbach, E. V. Minikel, H. T. Zhao, S. G. Guzman, A. J. Leed, M. F. Mesleh, H. B. Kordasiewicz, S. L. Schreiber, S. M. Vallabh

This study examines the binding and antiprion properties of antisense oligonucleotides (ASOs) targeting prion protein (PrP), finding that sequence-independent binding and aggregation occur, but only PrP-lowering ASOs are effective in vivo.

bioRxiv · Nov 7, 2019Biochemistry