Variability in the local and global composition of human T-cell receptor repertoires during thymic development across cell types and individuals
G. Isacchini, V. Quiniou, H. Vantomme, P. Stys, E. Mariotti-Ferandiz, D. Klatzmann, T. Mora, A. Walczak, A. Nourmohammad
The paper analyzes human TCR repertoires across thymic development stages and individuals, finding that inter-individual variability persists through maturation and that local sequence similarity correlates with cell type information.
bioRxiv · Jul 25, 2023 · PreprintImmunology