Structural basis for helicase-polymerase coupling in the SARS-CoV-2 replication-transcription complex
J. Chen, B. Malone, E. Llewellyn, M. Grasso, P. M. M. Shelton, P. D. B. Olinares, K. Maruthi, E. T. Eng, H. Vatandaslar, B. Chait, T. Kapoor, S. A. Darst, E. A. Campbell
The paper presents cryo-EM structures of the SARS-CoV-2 holo-RdRp complex with nsp13 helicase, revealing interactions and a new therapeutic target.
Cell · Sep 1, 2020Peer-reviewedBiophysics