Interleukin-15 Receptor α Chain Knockout NOD-SCID mice have reduced numbers of NK cells, develop thymic lymphomas and fail to engraft human hematopoietic cells
A. Vecchione, G. A. Nauman, M. Khosravi Marharlooei, N. M. Danzl, H. W. Li, E. Y. Chavez, B. E. Low, M. V. Wiles, D. Serreze, L. Ding, M. Sykes
This study shows that NOD-SCID mice lacking IL15R have reduced NK cells, accelerated lymphoma, and poor human hematopoietic engraftment.
bioRxiv · Apr 22, 2021 · PreprintImmunology