XRN1 deletion induces PKR-dependent cell lethality in interferon-activated cancer cells
T. Zou, M. Zhou, A. Gupta, P. Zhuang, A. R. Fishbein, H. Y. Wei, Z. Zhang, A. D. Cherniack, M. Meyerson
The paper shows that deleting XRN1 activates PKR and kills cancer cells with high interferon expression, suggesting XRN1 as a therapeutic target.
bioRxiv · Aug 1, 2023Cancer Biology