Author

A. D. Cherniack

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 4

Signature Assays, Organisms & Methods

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Organism:human· 4 Approach:experimental assay· 3 Research Focus:cancer & tumor microenvironment· 2 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Assay:bulk RNA-seq· 1 Research Focus:clustering· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

A. A. Borah· 1 shared A. C. Berger· 1 shared A. DenAdel· 1 shared A. Dias Costa· 1 shared A. Gupta· 1 shared A. J. Aguirre· 1 shared A. K. Shalek· 1 shared A. M. Jaeger· 1 shared

Activity by Year

2019-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 22 mutual co-author links

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1 shared paperCancer Biology

A. A. Borah

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4 papers

Recent·Most cited

XRN1 deletion induces PKR-dependent cell lethality in interferon-activated cancer cells

T. Zou, M. Zhou, A. Gupta, P. Zhuang, A. R. Fishbein, H. Y. Wei, Z. Zhang, A. D. Cherniack, M. Meyerson

The paper shows that deleting XRN1 activates PKR and kills cancer cells with high interferon expression, suggesting XRN1 as a therapeutic target.

bioRxiv · Aug 1, 2023Cancer Biology

High-resolution lung adenocarcinoma expression subtypes identify tumors with dependencies on MET, CDK4, CDK6, and PD-L1

W. Roh, Y. Geffen, M. Miller, S. Anand, J. Kim, D. Heiman, J. F. Gainor, P. W. Laird, A. D. Cherniack, National Cancer Institute Center for Cancer Genomics Tumor Molecular Pathology (TMP) AWG, G. Getz

The paper identifies five lung adenocarcinoma expression subtypes using consensus hierarchical clustering and finds subtype-specific dependencies on MET, CDK4, CDK6, and PD-L1, which could guide targeted therapies.

bioRxiv · Feb 20, 2022 · PreprintCancer Biology

The tumor microenvironment drives transcriptional phenotypes and their plasticity in metastatic pancreatic cancer

S. Raghavan, P. S. Winter, A. W. Navia, H. L. Williams, A. DenAdel, R. L. Kalekar, J. Galvez-Reyes, K. E. Lowder, N. Mulugeta, M. S. Raghavan, A. A. Borah, K. S. Kapner, S. A. Vayrynen, A. Dias Costa, R. W. S. Ng, , A. K. Shalek

This study identifies a transitional cancer cell state in metastatic pancreatic cancer and shows that tumor microenvironment signals drive transcriptional plasticity and subtype transitions.

bioRxiv · Aug 25, 2020 · PreprintCancer Biology

Loss of heterozygosity of essential genes represents a widespread class of potential cancer vulnerabilities

C. A. Nichols, W. J. Gibson, M. S. Brown, J. A. Kosmicki, J. P. Busanovich, H. Wei, L. M. Urbanski, N. Curimjee, A. C. Berger, G. F. Gao, A. D. Cherniack, S. Dhe-Paganon, B. R. Paolella, R. Beroukhim

The paper identifies LOH of essential genes as a class of non-driver cancer vulnerabilities by showing allele-specific inactivation can selectively kill cancer cells.

bioRxiv · Jan 29, 2019Cancer Biology