Structural basis of Cullin-2 RING E3 ligase regulation by the COP9 signalosome
S. V. Faull, A. Lau, C. Martens, Z. Ahdash, H. Yebenes, C. Schmidt, F. Beuron, N. B. Cronin, E. P. Morris, A. Politis
The paper determines the structure and dynamics of CSN-CRL2 complexes using cryo-EM and mass spectrometry, revealing a stepwise activation mechanism.
bioRxiv · Nov 29, 2018Biochemistry