Author

Z. Ahdash

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Biophysics· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:bacteria (other)· 2 Assay:cryo-EM· 1 Approach:deep learning· 1 Research Focus:drug response / drug discovery· 1 Research Focus:host-pathogen & immune response· 1 Research Focus:protein folding & dynamics· 1 Assay:protein structure· 1

Frequent Co-Authors

A. Politis· 3 shared A. Konijnenberg· 1 shared A. Lau· 1 shared A. Lawson· 1 shared A. M. Lau· 1 shared A. Macpherson· 1 shared A. V. Vargiu· 1 shared B. Holmes· 1 shared

Activity by Year

2018-2020 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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3 shared papersBiochemistry

A. Politis

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

The allosteric modulation of Complement C5 by knob domain peptides

A. Macpherson, M. Laabei, Z. Ahdash, M. A. Graewert, J. Birtley, S. Schulze, S. Crennell, S. Robinson, B. Holmes, V. Oleinikovas, P. H. Nilsson, J. Snowden, V. Ellis, T. E. Mollnes, C. M. Deane, , J. van den Elsen

This study shows that knob domain peptides modulate complement C5 through allosteric mechanisms, revealing new therapeutic inhibitors and introducing knob domains as low molecular weight antibody fragments.

bioRxiv · Oct 24, 2020Immunology

Perturbed structural dynamics underlie inhibition and altered specificity of the multidrug efflux pump AcrB

E. Reading, Z. Ahdash, C. Fais, V. Ricci, X. Wang-Kan, E. Grimsey, J. W. Stone, G. Malloci, A. M. Lau, H. Findlay, A. Konijnenberg, P. J. Booth, P. Ruggerone, A. V. Vargiu, L. J. V. Piddock, A. Politis

The paper investigates the structural dynamics of the AcrB efflux pump, showing how inhibitors and mutations affect its function and substrate specificity.

bioRxiv · Apr 27, 2020Biochemistry

HDX-MS reveals nucleotide-regulated, anti-correlated opening and closure of SecA and SecY channels of the bacterial translocon

Z. Ahdash, E. Pyle, W. J. Allen, R. A. Corey, I. Collinson, A. Politis

This study uses HDX-MS to show that ATP binding causes SecY to open and SecA to close, while ATP hydrolysis reverses this, supporting a Brownian ratchet mechanism for protein translocation.

bioRxiv · Apr 1, 2019Biophysics

Structural basis of Cullin-2 RING E3 ligase regulation by the COP9 signalosome

S. V. Faull, A. Lau, C. Martens, Z. Ahdash, H. Yebenes, C. Schmidt, F. Beuron, N. B. Cronin, E. P. Morris, A. Politis

The paper determines the structure and dynamics of CSN-CRL2 complexes using cryo-EM and mass spectrometry, revealing a stepwise activation mechanism.

bioRxiv · Nov 29, 2018Biochemistry