Saturation resistance profiling of EGFR variants against tyrosine kinase inhibitors using prime editing
Y. Kim, H.-C. Oh, S. Lee, H. H. Kim
This study introduces SynPrime, a prime editing-based method to evaluate EGFR variant resistance to TKIs, identifying functional effects of 2,476 SNVs and improving precision in therapeutic choices.
bioRxiv · Dec 3, 2023 · PreprintCancer Biology