Y. Kim

Microbiome-Targeted Reduction of Circulating Trimethylamine N-Oxide Mitigates Ischemic Stroke Risk

This study identifies Paracoccus aminovorans BM109 as a microbiome-targeted therapy that reduces TMAO levels and mitigates ischemic stroke risk in animal models.

A forward-engineered muscle tissue driven soft robotic swimmer

The paper builds a biohybrid robot with muscle-driven tail motion to study swimming dynamics and muscle adaptation, achieving speeds surpassing low-Reynolds number predictions.

IL-21 Shapes the B Cell Response in a Context-Dependent Manner

This study reveals that IL-21 regulates B cell fate through context-dependent effects on apoptosis and proliferation, using a conditional knock-out model and ex vivo cultures.

Cellular sialoglycans are differentially required for endosomal and cell-surface entry of SARS-CoV-2

This study shows sialoglycans promote endosomal, but not cell-surface, entry of SARS-CoV-2 and related sarbecoviruses.

Positive feedback between demographic and selective fluctuations can greatly amplify the random fluctuation of population size

This study shows that positive feedback between demographic and selective fluctuations can amplify population size variability by favoring mutations that increase fitness fluctuations.

Environmental drivers of Ixodes ricinus tick population dynamics: mechanistic modelling using longitudinal field surveys and climate data

This study models environmental drivers of Ixodes ricinus tick population dynamics using climate data and field surveys, finding temperature thresholds for life cycle stages and climate change impacts on tick abundance.

Benzylic Trifluoromethyl Accelerates 1,6-Elimination Toward Rapid Probe Activation

This paper introduces a fluorescent probe that rapidly detects hydrogen sulfide in live cells through a benzylic trifluoromethyl group-enhanced 1,6-elimination reaction.

Leukemia inhibitory factor (LIF) receptor amplifies pathogenic activation of fibroblasts in lung fibrosis

This study identifies LIFR as a master amplifier of fibroblast activation in IPF, showing that blocking LIFR reduces fibrosis in ex vivo tissue.

Biomarker Identification by Proteomic Analysis of Vitreous Humor and Plasma in Diabetic Retinopathy

This study identifies protein biomarkers in vitreous humor and plasma that predict diabetic retinopathy progression, with significant changes observed in vitreous samples of PDR patients.

High-throughput screening of more than 30,000 compounds for anthelmintics against gastrointestinal nematode parasites

This study screens over 30,000 compounds to identify new anthelmintics effective against gastrointestinal nematodes, finding 55 compounds with broad-spectrum activity.

Specialized Pericyte Subtypes in the Pulmonary Capillary

The paper identifies two specialized pericyte subtypes in pulmonary capillaries using Higd1b as a marker and shows their distinct functions and responses to hypoxia.

A single cell framework identifies functionally and molecularly distinct multipotent progenitors in adult human hematopoiesis

This study identifies new functionally and molecularly distinct multipotent progenitors in adult human hematopoiesis using multiomic single cell analyses and functional assays.

Estropausal gut microbiota transplant improves measures of ovarian function in adult mice

This study shows that transferring gut microbiota from young and estropausal mice improves ovarian function and fertility in adult mice.

Predicting immune checkpoint therapy response in three independent metastatic melanoma cohorts

The paper identifies six proteins that predict response to immune checkpoint therapy across three melanoma cohorts and correlate with patient survival.

Emergent survival and extinction of species within gut bacterial communities

The paper shows how species in gut bacterial communities can survive or go extinct based on resource availability and metabolic interactions, identifying emergent survival and community-driven extinctions.

MAPK-mediated PHGDH induction is essential for melanoma formation and represents an actionable vulnerability

This study identifies PHGDH induction via MAPK and mTORC1 pathways as essential for melanoma formation and shows that combining BRAFV600E inhibition with serine restriction can target this vulnerability.

An engineered human cardiac tissue model reveals contributions of systemic lupus erythematosus autoantibodies to myocardial injury

This study uses engineered human cardiac tissues to show how SLE autoantibodies affect myocardial injury through distinct binding patterns and functional effects on cardiac cells.

The effect of enriched versus inadequate housing conditions on eucalyptus smoke-induced cardiovascular dysfunction in mice

This study shows that enriched housing improves cardiopulmonary resilience to wildfire smoke in mice compared to depleted housing.

Thymidine Phosphorylase Mediates SARS-CoV-2 Spike Protein Enhanced Thrombosis in K18-hACE2TG Mice

This study identifies thymidine phosphorylase (TYMP) as a mediator of SARS-CoV-2 spike protein-induced thrombosis in mice, showing that TYMP inhibition reduces thrombosis and coagulation.

Identifying Ferroptosis Inducers, HDAC, and RTK Inhibitor Sensitivity in Melanoma Subtypes through Unbiased Drug Target Prediction

This paper identifies potential drug targets and predicts treatment efficacy and resistance in melanoma subtypes using proteogenomic data and drug sensitivity analysis.

Time resolved multi-omics reveals diverse metabolic strategies of Salmonella during diet-induced inflammation

This study uses multi-omics to analyze Salmonella's metabolic strategies in mice on different diets over time, identifying phase-specific gene expression linked to infection stages and therapeutic targets.

Mitotic waves in frog egg extracts: Transition from phase waves to trigger waves

The paper observes a transition from phase waves to trigger waves in Xenopus egg extracts and shows how these waves coordinate the cell cycle over long distances.

Nitrous oxide respiration in acidophilic methanotrophs

This study shows that two acidophilic methanotrophs can respire N2O and grow anaerobically, expanding their ecological niche and offering potential for greenhouse gas mitigation.

Impact of Capillary and Sarcolemmal Proximity on Mitochondrial Structure and Energetic Function in Skeletal Muscle

The paper compares mitochondrial structure and function in skeletal muscle based on proximity to capillaries or sarcolemma, finding capillary proximity enhances energy conversion and distribution.

Development of novel high-resolution melting markers for the assessment of hybridization between Mauremys sinensis and Mauremys reevesii in South Korea

This study develops high-resolution melting markers to detect hybridization between Mauremys sinensis and Mauremys reevesii in South Korea, identifying hybrid individuals at multiple sites.

AlphaFold2 structures template ligand discovery

This study evaluates AlphaFold2 models for ligand discovery, finding they perform similarly to experimental structures despite conformational differences, and identify potent agonists for the 5-HT2A receptor.

Saturation resistance profiling of EGFR variants against tyrosine kinase inhibitors using prime editing

This study introduces SynPrime, a prime editing-based method to evaluate EGFR variant resistance to TKIs, identifying functional effects of 2,476 SNVs and improving precision in therapeutic choices.

Assessing Tumor Microenvironment Characteristics and Stratifying EPR with a Nanobubble Companion Nanoparticle via Contrast-Enhanced Ultrasound Imaging

This paper uses contrast-enhanced ultrasound imaging with nanobubbles to assess tumor microenvironment characteristics and predict nanoparticle distribution in tumors with different vascular permeability.

Herbicidal Quassinoids Isolated from Ailanthus altissima Leaves

The paper isolates and characterizes quassinoids from Ailanthus altissima leaves and evaluates their herbicidal activity against various weeds.

BHLHE40 drives protective polyfunctional CD4 T cell differentiation in the female reproductive tract against Chlamydia

This study identifies BHLHE40 as a key driver of polyfunctional CD4 T cell differentiation in the female reproductive tract against Chlamydia, showing its role in limiting bacterial shedding.