Author

H. H. Kim

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioengineering· 2 Cancer Biology· 1 Plant Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:gene regulatory network inference· 2 Assay:whole-genome sequencing· 2 Organism:Arabidopsis· 1 Research Focus:benchmarking· 1 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1 Approach:deep learning· 1

Frequent Co-Authors

H. Jang· 2 shared J.-S. Kim· 2 shared Y. Kim· 2 shared B.-S. Park· 1 shared D. Choi· 1 shared D. H. Jo· 1 shared D. H. Kang· 1 shared G. Yi· 1 shared

Activity by Year

2021-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersPlant Biology

H. Jang

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Saturation resistance profiling of EGFR variants against tyrosine kinase inhibitors using prime editing

Y. Kim, H.-C. Oh, S. Lee, H. H. Kim

This study introduces SynPrime, a prime editing-based method to evaluate EGFR variant resistance to TKIs, identifying functional effects of 2,476 SNVs and improving precision in therapeutic choices.

bioRxiv · Dec 3, 2023 · PreprintCancer Biology

Sniper2L, a high-fidelity Cas9 variant with high activity

Y.-h. Kim, N. Kim, I. Okafor, S. Choi, S. Min, J. Lee, K. Choi, J. Choi, V. Harihar, Y. Kim, J.-S. Kim, J. K. Lee, T. Ha, H. H. Kim

This paper develops Sniper2L, a high-fidelity Cas9 variant with improved specificity and retained high on-target activity, and introduces a deep-learning model to predict its activity.

bioRxiv · Dec 5, 2022Bioengineering

A merger between compatible but divergent genomes supports allopolyploidization in the Brassicaceae family

H. Shin, J. E. Park, H. R. Park, W. L. Choi, S. H. Yu, W. Koh, S. Kim, H. Y. Soh, N. E. Waminal, H. R. Belandres, J. Y. Lim, G. Yi, J. H. Ahn, J.-S. Kim, Y.-M. Kim, , J. H. Huh

This study investigates how genome divergence and compatibility contribute to the stabilization of hybrid genomes in an allopolyploid plant species.

bioRxiv · Sep 28, 2021 · PreprintPlant Biology

Prime editing enables precise genome editing in mouse liver and retina

H. Jang, J. H. Shin, D. H. Jo, J. H. Seo, G. Yu, R. Gopalappa, S.-R. Cho, J. H. Kim, H. H. Kim

This study demonstrates that prime editing can correct disease-causing mutations in adult mouse liver and retina, with minimal off-target effects.

bioRxiv · Jan 8, 2021 · PreprintBioengineering