Increased biosynthesis of acetyl-CoA in the yeast Saccharomyces cerevisiae by overexpression of a deregulated pantothenate kinase gene
J. Olzhausen, M. Grigat, L. Seifert, T. Ulbricht, H.-J. Schueller
This paper identifies a hyperactive pantothenate kinase variant in yeast that, when overexpressed with other CoA biosynthesis genes, increases CoA nucleotides 15-fold.
bioRxiv · May 25, 2021Bioengineering