Temperature-responsive structural reversibility of FGF21 and structure-based design of its variant with enhanced potency
Y.-E. Jung, K. W. Lee, J. H. Cho, D.-W. Bae, B.-G. Jeong, Y.-J. Jung, Y. J. An, K. Kim, G. S. Lee, L.-W. Kang, J. H. Moon, J.-H. Lee, E.-K. Kim, H.-S. Yim, S.-S. Cha
This study investigates the thermal behavior of FGF21 and designs a variant with enhanced therapeutic potency through structural analysis and mutagenesis.
bioRxiv · Nov 16, 2021 · PreprintBiochemistry