J. H. Cho

High Throughput Single Cell Proteomic Analysis of Organ Derived Heterogeneous Cell Populations by Nanoflow Dual Trap Single Column Liquid Chromatography

The paper presents a high-throughput proteomic method for analyzing single-cell heterogeneity in organ-derived cell populations using nanoDTSC.

Enhancing the anti-tumor efficacy of Bispecific T cell engagers via cell surface glycocalyx editing

This study develops BiTE-sialidase fusion proteins that enhance anti-tumor efficacy by desialylating tumor cells, improving T-cell activation and cytolysis in vitro and in vivo.

Islet primary cilia motility controls insulin secretion

This study shows that primary cilia in pancreatic beta cells move and this movement is essential for glucose-dependent insulin secretion.

Temperature-responsive structural reversibility of FGF21 and structure-based design of its variant with enhanced potency

This study investigates the thermal behavior of FGF21 and designs a variant with enhanced therapeutic potency through structural analysis and mutagenesis.

Single-cell transcriptomic profiling of healthy and fibrotic adult zebrafish liver reveals conserved cell identities and stellate cell activation phenotypes with human liver

This study uses scRNA-seq to compare healthy and fibrotic adult zebrafish liver with human liver, identifying conserved cell identities and fibrosis-related gene expression patterns.

Ultrafast immunostaining of organ-scale tissues for scalable proteomic phenotyping

The paper introduces eFLASH, a method for rapid, uniform labeling of organ-scale tissues, enabling scalable proteomic phenotyping across species and tissues.

Microbial Engraftment and Efficacy of Fecal Microbiota Transplant for Clostridium difficile Patients With and Without IBD

This study evaluates FMT efficacy in CDI patients with and without IBD, finding no difference in recurrence rates and showing engraftment depends on IBD treatment, not disease severity.