Specific detection of cell-free DNA derived from intestinal epithelial cells using methylation patterns
Roni Lehmann‐Werman, Aviad Zick, Cloud Peter Paweletz, Marisa W. Welch, Ayala Hubert, Miriam Maoz, Tal Davidy, Judith Magenheim, Sheina Piyanzin, Daniel Neiman, Joshua Moss, Hadar Golan, Eran Israeli, Matan Fischer, Eran Segal, , Yuval Dor
The paper identifies methylation patterns specific to intestinal epithelial cells to detect cell-free DNA in plasma, showing increased levels in advanced CRC compared to IBD and PDAC.
bioRxiv · Sep 5, 2018 · PreprintDevelopmental Biology