Cloud Peter Paweletz

A dynamic molecular glue targets a plastic MDA5 filament interface to stimulate innate immunity

This paper identifies MA2, a small-molecule agonist of MDA5 that enhances antiviral and antitumor immunity by dynamically stabilizing MDA5 filaments.

Drug tolerant persisters and immunotherapy persister cells exhibit cross-resistance and share common survival mechanisms

This study identifies common survival mechanisms between drug-tolerant persisters and immunotherapy persisters, showing they share reduced mitochondrial apoptotic sensitivity and cross-resistance to therapies.

Cancers modulate p53 truncal neoantigen display to evade T cell detection

This study identifies that cancers limit p53 neoantigen display on MHC molecules, evading T cell detection through immune selection and ERAP1-mediated destruction.

Baseline expression of c-Myc defines the tissue specificity of oncogenic K-Ras

The paper shows that low baseline c-Myc expression restricts oncogenic K-Ras activity in tissues, and this can be reversed by increasing c-Myc in the liver.

Specific detection of cell-free DNA derived from intestinal epithelial cells using methylation patterns

The paper identifies methylation patterns specific to intestinal epithelial cells to detect cell-free DNA in plasma, showing increased levels in advanced CRC compared to IBD and PDAC.