K978C CFTR restores essential epithelial function with greater efficiency than wildtype CFTR when expressed in CF airway cells.
Maximillian N. J. Woodall, Robert Tarran, Rhianna E. Lee, Hafssa Anfishi, Stella Prins, John Robert Counsell, Paola Vergani, Stephen L. Hart, Deborah Louise Baines
This study shows that K978C CFTR, which increases open probability, restores epithelial function more efficiently than wildtype CFTR in CF airway cells when expressed in the presence of CF sputum.
bioRxiv · Aug 10, 2022 · PreprintMolecular Biology