Airway succinate chemosensing induces CFTR-dependent anion secretion and mucus clearance which is impaired in cystic fibrosis.
Tábata Apablaza, Marisol Barros-Poblete, Livia Delpiano…·Carlos Alberto Flores
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University of Kansas Medical CenterORCID 0000-0002-8598-2642Unclaimed ORCID profile · follow to get notified of new preprints
3 papers
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Tábata Apablaza, Marisol Barros-Poblete, Livia Delpiano…·Carlos Alberto Flores
Sarah Z. Hanif, CheukMan Cherie Au, Ingrid Torregroza…·Kristy A. Brown
This study shows that loss of GPR52 in breast cancer cells increases cell clustering, EMT features, and tumor burden in zebrafish, suggesting GPR52 as a potential therapeutic target.
Maximillian N. J. Woodall, Robert Tarran, Rhianna E. Lee…·Deborah Louise Baines
This study shows that K978C CFTR, which increases open probability, restores epithelial function more efficiently than wildtype CFTR in CF airway cells when expressed in the presence of CF sputum.