Enhancing HBV-specific T cell responses through a combination of epigenetic modulation and immune checkpoint inhibition
Melanie Urbanek‐Quaing, Yin-Han Chou, Manoj Kumar Gupta, Katja Steppich, Birgit Bremer, Hagen Schmaus, Katja Deterding, Benjamin Maasoumy, Heiner H. Wedemeyer, Cheng‐Jian Xu, Anke R. M. Kraft, Markus Cornberg
This study shows that combining decitabine with PD-L1 enhances HBV-specific T cell responses in vitro by reversing epigenetic imprints and improving IFN-gamma levels.
Hepatology · Dec 19, 2024Peer-reviewedImmunology