Cheng‐Jian Xu

This study shows that HIV persistence accelerates immune aging in treated individuals, while certain antiretroviral drugs reduce it.

This study creates a spatial transcriptomics atlas of human tuberculosis and non-tuberculous mycobacterial granulomas, identifying distinct niches and immune signatures.

This study shows that combining decitabine with PD-L1 enhances HBV-specific T cell responses in vitro by reversing epigenetic imprints and improving IFN-gamma levels.

This study investigates how DNA methylation changes after BCG vaccination influence cytokine responses and identifies epigenetic pathways mediating genetic effects on immune responses.

This study uses longitudinal meta-regression to examine how DNA methylation effects on child health outcomes vary by timing, finding larger effects in childhood but noisier associations and time-specific signals.

CellDemux demultiplexes genetically labeled single-cell and single-nuclei libraries across modalities, achieving 88% donor assignment accuracy in benchmarking.

The paper identifies three nasal DNA methylation CpG sites that predict childhood allergic disease with high accuracy, validated across Dutch and US Hispanic children.

This study explores the physiological significance of genetic variants associated with COVID-19 severity using clinical, immunological, and multi-omics data from large cohorts, identifying pathways for prevention and therapy.

This study examines how immune-related traits evolved in ancient and modern European populations, finding that the Neolithic transition influenced cytokine production and disease susceptibility.

This study shows that infant RSV immunoprophylaxis with palivizumab alters nasal epithelial DNA methylation at age 6, affecting antiviral defense pathways but not asthma.

The paper identifies genetic variants influencing DNA methylation in blood and shows their associations with complex traits and diseases, but finds limited direct causality.

The paper introduces Decon2, a method to deconvolute bulk blood eQTL effects into immune cell subpopulations, showing high concordance with experimental and single-cell studies.