Modeling Hereditary Diffuse Leukoencephalopathy with Axonal Spheroids using microglia-sufficient brain organoids
Wei Jie Wong, Yi Zhu, Hai Ting Wang, Jia Wen Qian, Ziyi Li, Song Li, Zhao Yuan Liu, Wei Guo, Shuang Yan Zhang, Bing Su, Fang Ping He, Kang Wang, Florent Ginhoux
This study uses brain organoids to model HDLS, showing that CSF-1R mutations in microglia lead to metabolic changes and inflammation that impair neuronal cells.
eLife · May 21, 2025Peer-reviewedNeuroscience