NeuroscienceeLifePeer-reviewed
Modeling Hereditary Diffuse Leukoencephalopathy with Axonal Spheroids using microglia-sufficient brain organoids
Wei Jie Wong, Yi Zhu, Hai Ting Wang…·Florent Ginhoux
This study uses brain organoids to model HDLS, showing that CSF-1R mutations in microglia lead to metabolic changes and inflammation that impair neuronal cells.