Structural basis for differential inhibition of THIK1 by chemically related inhibitors
Ran Zhang, Xiangyun Fang, Ruiheng Zhang, Zixue Wang, Haicao Jin, Boxuan Wang, Wei Wang, Xiaofang Zhong, Jin Qiang Wang, Baobin Li
This study determines the structural basis for differential inhibition of THIK1 by chemically related inhibitors using cryo-EM, showing how they affect different gates despite sharing a common binding site.
bioRxiv · Sep 24, 2026 · PreprintBiophysics