BiophysicsbioRxivPreprint
Structural basis for differential inhibition of THIK1 by chemically related inhibitors
Ran Zhang, Xiangyun Fang, Ruiheng Zhang…·Baobin Li
This study determines the structural basis for differential inhibition of THIK1 by chemically related inhibitors using cryo-EM, showing how they affect different gates despite sharing a common binding site.
DOI 10.64898/2026.09.21.753137