Author

Xiaofang Zhong

Peking University

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Biology Disciplines

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Biophysics· 1 Synthetic Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:benchmarking· 1 Approach:deep learning· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Organism:human· 1 Research Focus:protein design· 1 Assay:protein sequence· 1 Assay:protein structure· 1

Frequent Co-Authors

Baobin LiiD· 1 shared Boxuan WangiD· 1 shared Chenxin Wu· 1 shared Chuan ShaniD· 1 shared Haicao Jin· 1 shared Jin Qiang WangiD· 1 shared Jiong YuiD· 1 shared Lei Lu· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperBiophysics

Baobin LiORCID

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2 papers

Recent·Most cited

De novo design of metalloenzymes using Metal Mer

Chuan Shan, Zhuoyun Ren, Jiong Yu, Yuan Gao, Chenxin Wu, Xiaofang Zhong, Lei Lu

This paper introduces a computational pipeline for de novo metalloenzyme design using Metal Mer, achieving high selectivity and activity in catalytic reactions without directed evolution.

bioRxiv · Oct 16, 2026 · PreprintSynthetic Biology

Structural basis for differential inhibition of THIK1 by chemically related inhibitors

Ran Zhang, Xiangyun Fang, Ruiheng Zhang, Zixue Wang, Haicao Jin, Boxuan Wang, Wei Wang, Xiaofang Zhong, Jin Qiang Wang, Baobin Li

This study determines the structural basis for differential inhibition of THIK1 by chemically related inhibitors using cryo-EM, showing how they affect different gates despite sharing a common binding site.

bioRxiv · Sep 24, 2026 · PreprintBiophysics