Latent transforming growth factor binding protein-2 (LTBP2), an IPF biomarker of clinical decline, promotes TGF-beta signaling and lung fibrosis in mice
Nicholas K. Bodmer, Malay Choudhury, Haider Mirza, Suramamayi Pradhan, Yongjun Yin, Robert P. Mecham, Steven L. Brody, David M. Ornitz, Jeffrey R. Koenitzer
This study shows LTBP2 promotes TGF-beta signaling and lung fibrosis in mice but is also needed for epithelial repair.
American Journal of Respiratory Cell and Molecular Biology · Jun 2, 2026Peer-reviewedPathology