Jeffrey R. Koenitzer

E2F1 Drives Endothelial Arterial Programming in Pulmonary Arterial Hypertension

This study identifies E2F1 as a driver of pulmonary arterial hypertension by linking endothelial cell-cycle activation to arterial programming and vascular remodeling, showing that its inhibition mitigates disease in models.

Latent transforming growth factor binding protein-2 (LTBP2), an IPF biomarker of clinical decline, promotes TGF-beta signaling and lung fibrosis in mice

This study shows LTBP2 promotes TGF-beta signaling and lung fibrosis in mice but is also needed for epithelial repair.

Targeting the DNA damage repair protein RAD51 alters fibroblast metabolism and enhances apoptosis in pulmonary fibrosis

This study shows that inhibiting RAD51 in fibroblasts reduces fibrosis by promoting apoptosis and metabolic changes.

Comparative Single-Cell Transcriptomics Uncovers Shared and Distinct Molecular Signatures in Cystic Fibrosis and Primary Ciliary Dyskinesia

This study compares single-cell transcriptomes of Cystic Fibrosis and Primary Ciliary Dyskinesia to identify distinct molecular signatures and pathways.

Loss of an extensive ciliary connectome induces proteostasis and cell fate switching in a severe motile ciliopathy

The paper identifies cellular defects beyond motility loss in ciliopathies caused by CCDC39/CCDC40 variants, showing proteostasis disruption and cell fate switching.

Identification of a myofibroblast differentiation program during neonatal lung development

The paper identifies a myofibroblast differentiation program during neonatal lung development using single-cell RNA sequencing and lineage tracing in mice.

Single nucleus RNASeq profiling of mouse lung: reduced dissociation bias and improved detection of rare cell types compared with single cell RNASeq

This study compares single nucleus RNASeq (snRNASeq) and single cell RNASeq (scRNASeq) in mouse lung, finding snRNASeq reduces dissociation bias and better detects rare cell types.