Context-dependent translation inhibition as a novel oncology therapeutic modality
Paige D. Diamond, Paul Victor Sauer, Mikael Holm, Canessa J. Swanson-Swett, Lucas Ferguson, Natalie M. Bratset, Grant W. Wienker, Justin Seiwert Sim, Hailey K. Adams, Lillian Kenner, Margot Meyers, David Gygi, Zef A. Könst, Sogole Sami Bahmanyar, Lawrence G. Hamann, Anthony P. Schuller
This paper develops interdictors that selectively inhibit translation elongation in the human ribosome, showing their efficacy in tumor growth inhibition in a breast cancer model.
bioRxiv · Jan 9, 2025 · PreprintCancer Biology