Development of Second-Generation Acyl Silane Photoaffinity Probes for Cellular Chemoproteomic Profiling
Annika C. S. Page, Lauren M. Orr, Margot Meyers, Bridget P. Belcher, Theodore G. Coffey, Spencer O. Scholz, Sabine Cismoski, Daniel K. Nomura, F. Dean Toste
This paper develops second-generation acyl silane photoaffinity probes for cellular chemoproteomic profiling, showing improved labeling properties compared to existing diazirine-based probes.
ACS Chemical Biology · Oct 12, 2025Peer-reviewedBiochemistry