Sp Transcription Factors Establish the Signaling Environment in the Neuromesodermal Progenitor Niche During Axial Elongation
Ravindra B. Chalamalasetty, Haley Tran, Ryan Kelly, Samuel Kuo, Mark W. L. Kennedy, Moonsup Lee, Sara Thomas, Nikolaos Panagiotis Mandalos, Vishal N. Kopardé, Francisco Pereira Lobo, Terry P. Yamaguchi
The paper identifies Sp5/8 as essential regulators of neuromesodermal progenitor maintenance through their role in sustaining Wnt/Fgf signaling and repressing retinoic acid activity.
bioRxiv · Jun 3, 2025 · PreprintDevelopmental Biology