A dengue monovalent vaccine with novel structure provides cross-protection against four serotypes of dengue virus
Day-Yu Chao, Wen-Fan Shen, Jedhan Ucat Galula, Jiun-Hung Liu, Mei-Ying Liao, Chang-Hao Huang, Yu-Chun Wang, Han-Chung Wu, Jian-Jong Liang, Yi-Ling Lin, Matthew T. Whitney, Gwong-Jen J. Chang, Sheng-Ren Chen, Shang-Rung Wu
This study shows that a dengue vaccine based on matured DENV2 virus-like particles induces broad neutralizing antibodies against all four dengue serotypes and provides cross-protection in mice.
bioRxiv · Mar 5, 2018 · PreprintMicrobiology