ca-circSCN8A promotes HPASMCs ferroptosis via LLPS initiated R-Loop
Mengnan Li, Yingying Hao, Xinyue Song, Huiyu Liu, Chi Zhang, Jiaqi Zhang, Hanliang Sun, Xiaodong Zheng, Lixin Zhang, Hang Yu, Cui Ma, Xijuan Zhao, Daling Zhu
This study identifies ca-circSCN8A as a promoter of ferroptosis in HPASMCs under hypoxia by forming R-loops via LLPS of ca-circSCN8A/FUS/EP300, disrupting redox balance and contributing to pulmonary hypertension.
bioRxiv · Jan 21, 2025 · PreprintMolecular Biology