ca-circSCN8A promotes HPASMCs ferroptosis via LLPS initiated R-Loop
Mengnan Li, Yingying Hao, Xinyue Song…·Daling Zhu
This study identifies ca-circSCN8A as a promoter of ferroptosis in HPASMCs under hypoxia by forming R-loops via LLPS of ca-circSCN8A/FUS/EP300, disrupting redox balance and contributing to pulmonary hypertension.