Gut Competition Dynamics of Live Bacterial Therapeutics Are Shaped by Microbiome Complexity, Diet, and Therapeutic Transgenes
Nicole Siguenza, Sharyl Bailey, Mohammad Sadegi, Hanna Gootin, Maria Denalene Tiu, Jeffrey D. Price, Amanda E. Ramer‐Tait, Amir Zarrinpar
This study investigates factors affecting competition dynamics of live bacterial therapeutics in the murine gut, finding that microbiome complexity, diet, and transgenes influence their engraftment and efficacy.
bioRxiv · Jan 21, 2025 · PreprintMicrobiology