Amir Zarrinpar

The paper identifies microbial bile acid conjugation as a drug-activating function for 5-ASA, revealing its therapeutic relevance through metabolomics analysis.

The paper improves rRNA depletion for mouse cecal metatranscriptome analysis by designing probes based on sequence abundance rather than taxonomy, increasing mRNA reads and reducing bias.

This study investigates factors affecting competition dynamics of live bacterial therapeutics in the murine gut, finding that microbiome complexity, diet, and transgenes influence their engraftment and efficacy.

The paper shows that sample collection time significantly affects microbiome study conclusions, more than experimental interventions or dietary changes.

This study uses native E. coli as chassis to deliver transgenes, inducing persistent physiological changes in conventionally-raised hosts.