Metastasis founder cells activate immunosuppression early in human melanoma metastatic colonization
Severin Guetter, Courtney König, Huiqin Koerkel-Qu, Aleksandra Markiewicz, Sebastian Scheitler, Marie Katzer, Mark Berneburg, Philipp Renner, Beatrix Cucuruz, Leonhard Guttenberger, Veronika Naimer, Kathrin Weidele, Steffi Treitschke, Christian Werno, Hanna Jaser, , Melanie Werner‐Klein
This study identifies MCSP+ melanoma cells as early metastasis founder cells in lymph nodes and shows they activate immunosuppression to evade CD8 T cell attack.
Nature Cancer · May 16, 2025Peer-reviewedCancer Biology