Melanie Werner‐Klein

Metastatic founder cell candidates resemble preimplantation embryonic blastomeres

The paper identifies metastatic founder cell candidates in bone marrow that resemble preimplantation embryonic blastomeres, linking cancer metastasis to early embryonic development mechanisms.

Ex vivo drug testing in metastatic biopsies reveals patient-specific vulnerabilities to cancer targeting and immune activating drugs

This study introduces PEDRA, an ex vivo drug response assay that identifies patient-specific treatment options in metastatic biopsies, outperforming prior therapies and informing immune responses.

Metastasis founder cells activate immunosuppression early in human melanoma metastatic colonization

This study identifies MCSP+ melanoma cells as early metastasis founder cells in lymph nodes and shows they activate immunosuppression to evade CD8 T cell attack.

Retrospective cell lineage reconstruction in Humans using short tandem repeats

This paper introduces a method to reconstruct human cell lineages using STR mutations and demonstrates its application on melanoma and DU145 cell lines.