Christoph A. Klein

The paper identifies metastatic founder cell candidates in bone marrow that resemble preimplantation embryonic blastomeres, linking cancer metastasis to early embryonic development mechanisms.

This study introduces PEDRA, an ex vivo drug response assay that identifies patient-specific treatment options in metastatic biopsies, outperforming prior therapies and informing immune responses.

This study identifies MCSP+ melanoma cells as early metastasis founder cells in lymph nodes and shows they activate immunosuppression to evade CD8 T cell attack.

This paper introduces a method to reconstruct human cell lineages using STR mutations and demonstrates its application on melanoma and DU145 cell lines.

The paper shows that transcription starts much earlier in mouse and human one-cell embryos than previously thought, driven mainly by the maternal genome.

The paper develops a single-cell qPCR assay to accurately quantify ERBB2 expression in disseminated cancer cells, showing it can detect expression even in HER2-negative cells.