Dynamic reorganization of Developmental to Adult Genome Topology Controls the Initiation and Stabilization of the Human Muscle Stem Cell State
Matthew A. Romero, Peggie Chien, Chiara Nicoletti, Hanna L Liliom, Gabriella Cox, Emily Skuratovsky, Kholoud K. Saleh, Devin Gibbs, Lily Gane, Dieu-Huong Hoang, Luca Caputo, Jimmy Massenet, Débora R. Sobreira, Prem Puri, April D. Pyle
The paper identifies 3D chromatin changes during human muscle stem cell state transition, showing increased CTCF binding at PAX7 enhancers stabilizes the stem cell state.
bioRxiv · Jan 25, 2026 · PreprintDevelopmental Biology