Prem Puri

This study shows that Ctcf deficiency in myofibers leads to genome reprogramming and myopathy by disrupting 3D genome structure and gene regulation.

This study identifies SAA1-TLR4 signaling as a tumor-derived pathway driving muscle wasting in pancreatic cancer, showing that targeting this pathway can preserve muscle mass and improve survival without affecting tumor growth.

This paper introduces SHARP, a method to enhance Hi-C data resolution while avoiding artificial structures by decomposing signals and using multi-scale attention.

The paper identifies EPR as an oncosuppressor in intestinal cancer, showing its role in goblet cell development and its potential as a prognostic marker and therapeutic target.

The paper identifies 3D chromatin changes during human muscle stem cell state transition, showing increased CTCF binding at PAX7 enhancers stabilizes the stem cell state.

This study identifies Tenascin-C as a key factor promoting muscle stem cell self-renewal through Annexin A2 signaling, showing its role in muscle repair and aging.

The paper shows that modulating the JAK2-STAT3 pathway enhances the yield and maturation of human iPSC-derived myogenic progenitor cells for potential cell therapy.

The paper investigates how three-dimensional chromatin domain structures influence gene regulation and finds that domain surfaces are enriched for regulatory elements and disease variants.

This paper identifies a new function of MYOD as a transcriptional repressor through E-box-independent chromatin binding, revealing a mechanism to repress gene expression and maintain cell identity during myogenesis.