Débora R. Sobreira

The paper investigates the role of the EPAS1 enhancer ENH5 in adipocytes, showing its conditional effects on thermogenesis and adipocyte differentiation under hypoxia and thermogenic stimulation.

The paper identifies 3D chromatin changes during human muscle stem cell state transition, showing increased CTCF binding at PAX7 enhancers stabilizes the stem cell state.

The paper integrates GWAS data with functional genomic annotations of decidual stromal cells to identify loci and target genes associated with gestational duration and preterm birth.

The paper identifies a regulatory region near the IL33 gene that influences asthma risk through allele-specific expression and OCT-1 binding.

The paper generates promoter interaction maps in human iPSCs and cardiomyocytes to link CVD-associated SNPs to target genes, showing most SNPs interact with non-nearest genes.