Author

Hannah Demanche

University of Massachusetts Amherst

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Cell Biology· 1

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Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Organism:human· 1 Research Focus:protein folding & dynamics· 1 Assay:proteomics· 1

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Andrew ShultziD· 1 shared Anna Vincze· 1 shared Emma L. Poirier· 1 shared Jennifer N. RauchiD· 1 shared Todd T. Yau· 1 shared

Activity by Year

2025-2025 · peak 1/yr

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5 top collaborators · 10 mutual co-author links

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1 shared paperCell Biology

Andrew ShultzORCID

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1 paper

Recent·Most cited

Extracellular tau clearance is governed by its aggregation state and independent of microglial activation by LPS and IFN-γ

Andrew Shultz, Anna Vincze, Todd T. Yau, Emma L. Poirier, Hannah Demanche, Jennifer N. Rauch

This study shows that human iPSC-derived microglia internalize and clear tau differently based on its aggregation state, and that acute inflammation does not affect tau clearance.

Neurobiology of Disease · Aug 18, 2025Peer-reviewedCell Biology