Jennifer N. Rauch

This study identifies small-molecule inhibitors of the tau-LRP1 interaction using biochemical assays and high-throughput screening, showing reduced tau uptake in cellular assays.

This study shows zinc modulates tau aggregation and seeding differently based on tau sequence context, highlighting cofactor effects depend on sequence and conformational constraints.

This study shows that human iPSC-derived microglia internalize and clear tau differently based on its aggregation state, and that acute inflammation does not affect tau clearance.

This paper presents a scalable, easy-to-deploy protocol for detecting SARS-CoV-2 genetic material using Cas13-based technology paired with PCR and low-cost instrumentation.

The paper identifies the proline-rich domain (PRD) of tau as a driver of liquid-liquid phase separation (LLPS) in cells, showing its phosphorylation-dependent behavior and interaction with microtubules.

Lonafarnib reduces tau pathology in a tauopathy mouse model by targeting Rhes to enhance lysosomal degradation.

The paper identifies 6-O-sulfation on heparan sulfate proteoglycans as critical for tau internalization and shows it regulates uptake in multiple cell models.