Author

Emma L. Poirier

University of Massachusetts Amherst

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 2 Approach:experimental assay· 2 Research Focus:protein folding & dynamics· 2 Research Focus:cell-cell communication· 1 Research Focus:differential expression· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Assay:protein structure· 1

Frequent Co-Authors

Jennifer N. RauchiD· 2 shared Alyssa Stainton· 1 shared Ana B. Varona Ortiz· 1 shared Andrew ShultziD· 1 shared Anna Vincze· 1 shared Hannah Demanche· 1 shared Oskar Simon· 1 shared Sally A. KimiD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersBiochemistry

Jennifer N. RauchORCID

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2 papers

Recent·Most cited

Zinc Differentially Modulates Tau Aggregation, Fibril Morphology, and Prion-like Seeding in a Construct-Dependent Manner

Emma L. Poirier, Alyssa Stainton, Oskar Simon, Suhana S. Mittal, Ana B. Varona Ortiz, Sally A. Kim, Jennifer N. Rauch

This study shows zinc modulates tau aggregation and seeding differently based on tau sequence context, highlighting cofactor effects depend on sequence and conformational constraints.

bioRxiv · Jul 2, 2026 · PreprintBiochemistry

Extracellular tau clearance is governed by its aggregation state and independent of microglial activation by LPS and IFN-γ

Andrew Shultz, Anna Vincze, Todd T. Yau, Emma L. Poirier, Hannah Demanche, Jennifer N. Rauch

This study shows that human iPSC-derived microglia internalize and clear tau differently based on its aggregation state, and that acute inflammation does not affect tau clearance.

Neurobiology of Disease · Aug 18, 2025Peer-reviewedCell Biology