HDAC5-encoded Microprotein NISM Mediates Nucleolar Formation and Ribosomal RNA Synthesis
Kevin Cao, Dat P. Ha, Jesse Hulahan, L. L. Houston, Gregory Tong, Jiayi Weng, Natasha Huey, Hannah Demerit, Pedro Ortega, Rémi Buisson, Kingshuk Ghosh, Thomas Farid Martinez
The paper identifies NISM, a microprotein encoded by HDAC5, which regulates nucleolar formation and rRNA synthesis by modulating DHX9 activity and phase separation.
bioRxiv · Feb 22, 2026 · PreprintMolecular Biology