Author
University of California, IrvineORCID 0000-0002-7196-8209Unclaimed ORCID profile · follow to get notified of new preprints
4 papers
Recent·Most cited
Kevin Cao, Dat P. Ha, Jesse Hulahan, L. L. Houston, Gregory Tong, Jiayi Weng, Natasha Huey, Hannah Demerit, Pedro Ortega, Rémi Buisson, Kingshuk Ghosh, Thomas Farid Martinez
The paper identifies NISM, a microprotein encoded by HDAC5, which regulates nucleolar formation and rRNA synthesis by modulating DHX9 activity and phase separation.
bioRxiv · Feb 22, 2026 · PreprintMolecular Biology
Dimitrios Papaioannou, Amog P. Urs, Rémi Buisson, Andreas Petri, Mingjun Liu, Lauren A. Woodward, Rohan Kulkarni, Xenia Weislämle, Olha Ivashkiv, Deedra Nicolet, Chinmayee Goda, Varvara Paraskevopoulou, Yaphet Bustos, Krzysztof Mrózek, Ann‐Kathrin Eisfeld, , Ramiro Garzon
This study identifies circPCMTD1 as a circular RNA that promotes leukemic cell proliferation by enhancing DNA damage response tolerance through a novel peptide product.
Blood · Jan 29, 2026Peer-reviewedCancer Biology
Pedro Ortega, Elodie Bournique, Junyi Li, Ambrocio Sanchez, Gisselle Santiago, Brooke R. Harris, Josefine Striepen, John Maciejowski, Abby M. Green, Rémi Buisson
This study identifies APOBEC3B as the enzyme responsible for ssDNA breakage during replication catastrophe induced by ATR inhibition, revealing a mechanism for PARP1 trapping and synthetic lethality with PARP inhibitors.
Science Advances · Apr 16, 2025Peer-reviewedMolecular Biology
Lavanya Manjunath, Gisselle Santiago, Pedro Ortega, Ambrocio Sanchez, Sunwoo Oh, Alexander Nathaniel Garcia, Junyi Li, Dana Duong, Elodie Bournique, Alexis Bouin, Bert L. Semler, Dheva Setiaputra, Rémi Buisson
The paper identifies PACT as a key inhibitor of PKR during viral infection and shows that PACT and ADAR1 cooperate to prevent aberrant PKR activation by self-dsRNAs.
Nature Communications · Apr 5, 2025Peer-reviewedMicrobiology