HES1 oscillations are required for cell cycle re-entry in oestrogen receptor positive breast cancer cells
Oliver Cottrell, Andrew Rowntree, Kunal Chopra, Eleanor Mackellar, Benjamin Noble, Hannah Dixon, Ciara Healy, Robert B. Clarke, Nancy Papalopulu
This study shows that HES1 protein oscillations are necessary for ER+ breast cancer cells to re-enter the cell cycle, and disrupting these oscillations prevents reactivation of dormant cells.
bioRxiv · Aug 4, 2025 · PreprintCancer Biology