Decades-long elevation of interferon-alpha drives a Sjogren disease endotype: an interdisciplinary study
Deborah Forbes, Ivana Jorgacevic, Jessica R. Tarn, Katy R Reid, Bastien Rioux, Kyle Thompson, Kilian L. Kleemann, Sarah L. McGlasson, John Casement, Joe Scott Berry, Patrick Müller, Hannah Eberle-Reece, Christa Haase, Brendan Conn, Louis Boon, , David P J Hunt
This study shows that chronic elevation of interferon-alpha drives a specific immune endotype of Sjogren disease, detectable up to 14 years before diagnosis.
bioRxiv · Aug 6, 2025 · PreprintImmunology