Axel Roers

This study shows that chronic elevation of interferon-alpha drives a specific immune endotype of Sjogren disease, detectable up to 14 years before diagnosis.

This study shows that systemic TREX1 inhibition enhances anti-tumor immunity by increasing T cell infiltration and activity in tumors while sparing other tissues.

The paper uses fate-mapping, single-cell RNA-sequencing, and computational methods to show that major hematopoietic lineages diverge within HSCs, identifying a self-renewing HSC subpopulation and a direct thrombopoiesis pathway.