Author

John Casement

Newcastle UniversityORCID 0000-0003-3514-7259Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Bioinformatics· 1 Immunology· 1 Molecular Biology· 1 Systems Biology· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 3 Research Focus:differential expression· 3 Organism:human· 3 Research Focus:benchmarking· 2 Approach:statistical model· 2 Research Focus:cell type annotation· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Adam R. CreighiD· 1 shared Amy FoulkesiD· 1 shared Anna JirkovskáiD· 1 shared Ashley Rider· 1 shared Axel RoersiD· 1 shared Bastien RiouxiD· 1 shared Brendan ConniD· 1 shared Caroline A. AustiniD· 1 shared

Activity by Year

2025-2026 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 12 mutual co-author links

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1 shared paperMolecular Biology

Adam R. CreighORCID

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4 papers

Recent·Most cited

BioinformaticsbioRxivPreprintOct 5, 2026

EndoMT: An R Package Resource for Endothelial-Mesenchymal Transition Gene Set Enrichment Analysis

Katie Best, John Casement, Penny E. Lovat…·Jane L. Armstrong

The paper introduces an R package for EndoMT gene set enrichment analysis, showing its utility in detecting EndoMT-associated transcriptional changes across different experimental conditions.

DOI 10.64898/2026.09.29.755303

humanbulk RNA-seq

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Molecular BiologyBiology OpenPeer-reviewedAug 12, 2026

Analysis of Gene Expression Changes upon Topobexin Treatment and TOP2B-knockout in hiPSC derived cardiomyocytes

Veronika Keresteš, Ian Cowell, Anna Jirkovská…·Caroline A. Austin

The paper examines gene expression changes in hiPSC-derived cardiomyocytes with TOP2B deletion or treated with topobexin, showing topobexin phenocopies TOP2B knockout.

DOI 10.1242/bio.062592

humanbulk RNA-seq

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Systems BiologyCommunications MedicinePeer-reviewedJan 21, 2026

Transcriptomic profiling and machine learning uncover gene signatures of psoriasis endotypes and disease severity

Ashley Rider, Henry J. Grantham, Graham R. Smith…·Nick J. Reynolds

3 citationstop 3%

humanbulk RNA-seq

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ImmunologybioRxivPreprintAug 6, 2025

Decades-long elevation of interferon-alpha drives a Sjogren disease endotype: an interdisciplinary study

Deborah Forbes, Ivana Jorgacevic, Jessica R. Tarn…·David P J Hunt

This study shows that chronic elevation of interferon-alpha drives a specific immune endotype of Sjogren disease, detectable up to 14 years before diagnosis.

DOI 10.1101/2025.08.06.668845

mouseproteomics

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